TY - JOUR
T1 - The impact of prenatal environment on postnatal life and performance
T2 - Future perspectives for prevention and treatment
AU - Gonzalez-Bulnes, A.
AU - Parraguez, V. H.
AU - Berlinguer, F.
AU - Barbero, A.
AU - Garcia-Contreras, C.
AU - Lopez-Tello, J.
AU - Pesantez-Pacheco, J. L.
AU - Martinez-Ros, P.
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - The present review aims to offer a non-comprehensive outline of the current state-of-the-art and future perspectives on management and therapeutic tools for intrauterine growth restriction (IUGR) and associated prenatal programming in both human and animal species. Animals are used as models for the study of phenomena related to IUGR, but also for research on prenatal therapies with the main objective of designing and developing preventive and therapeutic strategies. The research is currently paying attention on maternal-focused pharmacological treatments and nutritional strategies but also on fetal-focused treatments. Fetal-focused treatments, administered either directly at the fetus or by using infusion of umbilical cord, amniotic sac or placenta, which avoids the administration of substances at high doses to the mother for allowing their availability at the fetoplacental level. The results obtained in this area of research using large animals (rabbits, pigs and ruminants) have a dual interest, for translational biomedicine and for veterinary medicine and animal production.
AB - The present review aims to offer a non-comprehensive outline of the current state-of-the-art and future perspectives on management and therapeutic tools for intrauterine growth restriction (IUGR) and associated prenatal programming in both human and animal species. Animals are used as models for the study of phenomena related to IUGR, but also for research on prenatal therapies with the main objective of designing and developing preventive and therapeutic strategies. The research is currently paying attention on maternal-focused pharmacological treatments and nutritional strategies but also on fetal-focused treatments. Fetal-focused treatments, administered either directly at the fetus or by using infusion of umbilical cord, amniotic sac or placenta, which avoids the administration of substances at high doses to the mother for allowing their availability at the fetoplacental level. The results obtained in this area of research using large animals (rabbits, pigs and ruminants) have a dual interest, for translational biomedicine and for veterinary medicine and animal production.
KW - Animal-models
KW - IUGR
KW - Prenatal-programming
KW - Translational-medicine
KW - Veterinary-medicine
UR - https://www.scopus.com/pages/publications/85078341788
U2 - 10.1016/j.theriogenology.2020.01.029
DO - 10.1016/j.theriogenology.2020.01.029
M3 - Artículo
C2 - 31983467
AN - SCOPUS:85078341788
SN - 0093-691X
VL - 150
SP - 15
EP - 19
JO - Theriogenology
JF - Theriogenology
ER -