Integrin α6 (CD49F), the microenvironment and cancer stem cells

Gabriele D. Bigoni-Ordóñez; Daniel Czarnowski; Tyler Parsons; Gerard J. Madlambayan; Luis G. Villa-Diaz

doi:10.2174/1574888X13666181002151330

Integrin α6 (CD49F), the microenvironment and cancer stem cells

Gabriele D. Bigoni-Ordóñez, Daniel Czarnowski, Tyler Parsons, Gerard J. Madlambayan, Luis G. Villa-Diaz

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

31 Citas (Scopus)

Resumen

Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in Cancer Stem Cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment.

Idioma original	Inglés
Páginas (desde-hasta)	428-436
Número de páginas	9
Publicación	Current Stem Cell Research and Therapy
Volumen	14
N.º	5
DOI	https://doi.org/10.2174/1574888X13666181002151330
Estado	Publicada - 2019
Publicado de forma externa	Sí

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abstract = "Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in Cancer Stem Cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment.",

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T1 - Integrin α6 (CD49F), the microenvironment and cancer stem cells

AU - Bigoni-Ordóñez, Gabriele D.

AU - Czarnowski, Daniel

AU - Parsons, Tyler

AU - Madlambayan, Gerard J.

AU - Villa-Diaz, Luis G.

PY - 2019

Y1 - 2019

N2 - Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in Cancer Stem Cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment.

AB - Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in Cancer Stem Cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment.

KW - Cancer stem cells

KW - Cell signalling

KW - Integrin α6

KW - Laminins

KW - Self-renewal

KW - Tumor microenvironment

UR - https://publicaciones.ucuenca.edu.ec/ojs/index.php/medicina/article/view/2991/2281

U2 - 10.2174/1574888X13666181002151330

DO - 10.2174/1574888X13666181002151330

M3 - Artículo

C2 - 30280675

AN - SCOPUS:85069932887

SN - 1574-888X

VL - 14

SP - 428

EP - 436

JO - Current Stem Cell Research and Therapy

JF - Current Stem Cell Research and Therapy

IS - 5

ER -

Integrin α6 (CD49F), the microenvironment and cancer stem cells

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