Remineralización biomimética de esmalte y dentina: una revisión de la literatura

Objective. To analyze the literature regarding enamel and dentin remineralization with biomimetic materials to understand their effectiveness and clinical applications. Methodology. Comprehensive research of scientific articles was conducted that included in vitro studies, systematic reviews, and meta-analyses published between 2019 and 2024. The databases consulted were Pubmed, Science Direct, and Springer Link and Google academic was used as a secondary search engine. Results. Despite all the promising studies, biomimetic strategies still face challenges in the field of dentistry. Conclusion. Biomimetic remineralization has evolved from an experimental concept to an emerging clinical reality, establishing P11-4 peptides, stabilized CPP-ACP dentifrices, and zinc-carbonate hydroxyapatite as viable therapeutic options for immediate implementation. The trend toward multifunctional materials combining remineralizing, antibacterial, and anti-adhesive properties represents a paradigmatic evolution that transcends traditional restorative approaches toward comprehensive tissue regeneration. Despite promising evidence, a critical gap persists between abundant laboratory research and limited clinical evidence requiring priority attention. Biomimetic remineralization possesses transformative potential to revolutionize preventive and therapeutic management of dental caries, transitioning toward a regenerative model that could significantly reduce the burden of oral disease at the population level. General Area of Study: Medicine. Specific area of study: Dentistry. Type of study: Systematic bibliographic review