TY - JOUR
T1 - Polyphenols and IUGR pregnancies
T2 - Maternal hydroxytyrosol supplementation improves prenatal and early-postnatal growth and metabolism of the offspring
AU - Vazquez-Gomez, Marta
AU - Garcia-Contreras, Consolación
AU - Torres-Rovira, Laura
AU - Pesantez, José Luis
AU - Gonzalez-Añover, Pedro
AU - Gomez-Fidalgo, Ernesto
AU - Sanchez-Sanchez, Raúl
AU - Ovilo, Cristina
AU - Isabel, Beatriz
AU - Astiz, Susana
AU - Gonzalez-Bulnes, Antonio
N1 - Publisher Copyright:
© 2017 Vazquez-Gomez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/5
Y1 - 2017/5
N2 - Hydroxytyrosol is a polyphenol with antioxidant, metabolism-regulatory, anti-inflammatory and immuno-modulatory properties. The present study aimed to determine whether supplementing the maternal diet with hydroxytyrosol during pregnancy can improve pre-and early post-natal developmental patterns and metabolic traits of the offspring. Experiment was performed in Iberian sows fed a restricted diet in order to increase the risk of IUGR. Ten sows were treated daily with 1.5 mg of hydroxytyrosol per kg of feed between Day 35 of pregnancy (30% of total gestational period) until delivery whilst 10 animals were left untreated as controls. Number and weight of offspring were assessed at birth, on post-natal Day 15 and at weaning (25 days-old). At weaning, body composition and plasma indexes of glucose and lipids were measured. Treatment with hydroxytyrosol was associated with higher mean birth weight, lower incidence of piglets with low birth weight. Afterwards, during the lactation period, piglets in the treated group showed a higher body-weight than control piglets; such effects were even stronger in the most prolific litters. These results suggest that maternal supplementation with hydroxytyrosol may improve pre-and early post-natal development of offspring in pregnancies at risk of IUGR.
AB - Hydroxytyrosol is a polyphenol with antioxidant, metabolism-regulatory, anti-inflammatory and immuno-modulatory properties. The present study aimed to determine whether supplementing the maternal diet with hydroxytyrosol during pregnancy can improve pre-and early post-natal developmental patterns and metabolic traits of the offspring. Experiment was performed in Iberian sows fed a restricted diet in order to increase the risk of IUGR. Ten sows were treated daily with 1.5 mg of hydroxytyrosol per kg of feed between Day 35 of pregnancy (30% of total gestational period) until delivery whilst 10 animals were left untreated as controls. Number and weight of offspring were assessed at birth, on post-natal Day 15 and at weaning (25 days-old). At weaning, body composition and plasma indexes of glucose and lipids were measured. Treatment with hydroxytyrosol was associated with higher mean birth weight, lower incidence of piglets with low birth weight. Afterwards, during the lactation period, piglets in the treated group showed a higher body-weight than control piglets; such effects were even stronger in the most prolific litters. These results suggest that maternal supplementation with hydroxytyrosol may improve pre-and early post-natal development of offspring in pregnancies at risk of IUGR.
UR - https://www.scopus.com/pages/publications/85019951445
U2 - 10.1371/journal.pone.0177593
DO - 10.1371/journal.pone.0177593
M3 - Artículo
C2 - 28545153
AN - SCOPUS:85019951445
SN - 1932-6203
VL - 12
JO - PLoS ONE
JF - PLoS ONE
IS - 5
M1 - e0177593
ER -