Abstract
Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in Cancer Stem Cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment.
| Original language | English |
|---|---|
| Pages (from-to) | 428-436 |
| Number of pages | 9 |
| Journal | Current Stem Cell Research and Therapy |
| Volume | 14 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2019 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer stem cells
- Cell signalling
- Integrin α6
- Laminins
- Self-renewal
- Tumor microenvironment
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