Heterogeneity of HPV genotypes in oropharyngeal condyloma accuminatum: Case report from Ecuador

Acuminated condyloma (AC), or venereal wart, is a viral infection caused by the human papillomavirus (HPV),
primarily transmitted through sexual contact. Adolescents and young adults are the most vulnerable
groups. Its presentation in the oral cavity is atypical, as is the involvement of HPV genotypes other than
HPV‑6/11/16/18. This report describes an unusual case of oropharyngeal condyloma in a young adult woman
with dyslipidaemia and vitamin D deficiency, which exhibited co‑infection with low‑risk (HPV‑6, 11) and
high‑risk oncogenic genotypes (HPV‑59, 82). The latter two genotypes have not been reported in oral or
oropharyngeal AC cases so far. Diagnosis was based on clinical and pathological findings, with a favourable
prognosis despite the lesion’s location. While AC diagnosis is primarily clinical, histopathological analysis
is crucial for distinguishing it from other HPV‑related oral conditions. Genotyping, though not essential
for diagnosis, has epidemiological relevance in guiding vaccination strategies.