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Fabrication of 3D bioactive ceramic scaffolds by robocasting

  • S. Andrade
  • , A. Abdalla
  • , E. Montufar
  • , L. Corté
  • , P. Vanegas

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Tricalcium phosphate ceramics are bioactive and osteoconductive biomaterials that support cellular functions and can develop appropriate mechanical characteristics for bone tissue engineering. Fast prototyping techniques permit to obtain accurate control over scaffolding architecture with high reproducibility. Flexible composites are considered to promote mechano-biological stimulation during cell culture. The aim of this study is to fabricate flexible bioceramic scaffolds by robocasting and to determine biological improvements related to their added flexible properties. Characterized 3D β - TCP/gelatin scaffolds with interconnected porous structure were fabricated using robocasting. SEM micrographs showed fabricated porous scaffolds with desired pore size (~200 μm), rods diameter (~840 μm), porosity and mechanical strength. Alamar Blue assay was performed for static and dynamic cultures along 21 days. Oscillatory flow conditions allowed considerable higher cell proliferation compared with static conditions.

Original languageEnglish
Title of host publicationVI Latin American Congress on Biomedical Engineering, CLAIB 2014
EditorsAriel Braidot, Alejandro Hadad
PublisherSpringer Verlag
Pages167-169
Number of pages3
ISBN (Electronic)9783319131160
DOIs
StatePublished - 2015
Event6th Latin American Congress on Biomedical Engineering, CLAIB 2014 - Paraná, Argentina
Duration: 29 Oct 201431 Oct 2014

Publication series

NameIFMBE Proceedings
Volume49
ISSN (Print)1680-0737

Conference

Conference6th Latin American Congress on Biomedical Engineering, CLAIB 2014
Country/TerritoryArgentina
CityParaná
Period29/10/1431/10/14

Keywords

  • Biomaterials
  • Bioreactor
  • Bone tissue engineering
  • Flexible scaffolds
  • Robocasting
  • Tricalcium phosphate

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