TY - JOUR
T1 - Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models
AU - Orellana-Paucar, Adriana Monserrath
AU - Serruys, Ann Sophie K.
AU - Afrikanova, Tatiana
AU - Maes, Jan
AU - De Borggraeve, Wim
AU - Alen, Jo
AU - León-Tamariz, Fabián
AU - Wilches-Arizábala, Isabel María
AU - Crawford, Alexander D.
AU - de Witte, Peter A.M.
AU - Esguerra, Camila V.
PY - 2012/5
Y1 - 2012/5
N2 - Turmeric, obtained from the rhizomes of Curcuma longa, is used in South Asia as a traditional medicine for the treatment of epilepsy. To date, in vivo studies on the anticonvulsant activity of turmeric have focused on its principal curcuminoid, curcumin. However, poor absorption and rapid metabolism have limited the therapeutic application of curcumin in humans. To explore the therapeutic potential of turmeric for epilepsy further, we analyzed its anticonvulsant activity in a larval zebrafish seizure assay. Initial experiments revealed that the anticonvulsant activity of turmeric in zebrafish larvae cannot be explained solely by the effects of curcumin. Zebrafish bioassay-guided fractionation of turmeric identified bisabolene sesquiterpenoids as additional anticonvulsants that inhibit PTZ-induced seizures in both zebrafish and mice. Here, we present the first report of the anticonvulsant properties of bisabolene sesquiterpenoids and provide evidence which warrants further investigation toward the mechanistic understanding of their neuromodulatory activity.
AB - Turmeric, obtained from the rhizomes of Curcuma longa, is used in South Asia as a traditional medicine for the treatment of epilepsy. To date, in vivo studies on the anticonvulsant activity of turmeric have focused on its principal curcuminoid, curcumin. However, poor absorption and rapid metabolism have limited the therapeutic application of curcumin in humans. To explore the therapeutic potential of turmeric for epilepsy further, we analyzed its anticonvulsant activity in a larval zebrafish seizure assay. Initial experiments revealed that the anticonvulsant activity of turmeric in zebrafish larvae cannot be explained solely by the effects of curcumin. Zebrafish bioassay-guided fractionation of turmeric identified bisabolene sesquiterpenoids as additional anticonvulsants that inhibit PTZ-induced seizures in both zebrafish and mice. Here, we present the first report of the anticonvulsant properties of bisabolene sesquiterpenoids and provide evidence which warrants further investigation toward the mechanistic understanding of their neuromodulatory activity.
KW - Ar-turmerone
KW - Bisabolene sesquiterpenoids
KW - Curcuma longa
KW - Mouse PTZ model
KW - Pentylenetetrazole
KW - Turmeric
KW - Turmeric oil
KW - Zebrafish PTZ model
KW - α,β-Turmerone
KW - α-Atlantone
UR - https://www.scopus.com/pages/publications/84860668697
U2 - 10.1016/j.yebeh.2012.02.020
DO - 10.1016/j.yebeh.2012.02.020
M3 - Artículo
C2 - 22483646
AN - SCOPUS:84860668697
SN - 1525-5050
VL - 24
SP - 14
EP - 22
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
IS - 1
ER -