TY - GEN
T1 - An aide diagnosis system based on k-means for insulin resistance assessment in eldery people from the Ecuadorian highlands
AU - Vintimilla, Christian
AU - Wong, Sara
AU - Astudillo-Salinas, Fabian
AU - Encalada, Lorena
AU - Severeyn, Erika
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2018/1/4
Y1 - 2018/1/4
N2 - The lack of standardized cut-off values for the surrogate methods to diagnose Insulin resistance (IR) and the fact that the sensitivity of these methods have been studied in specific populations have limited their use in clinical routine. We developed a system that could aide to diagnosis IR in elderly people, analyzing four surrogate methods of IR estimation using a k-means clustering algorithm. Study subjects included 119 nondiabetic participants over 65 year old from Ecuadorian highlands. Blood tests included a two-point oral glucose test tolerance. The k-means clustering algorithm, was applied in one-dimensional experiments for the Homa-IR, Quicki, Avignon and Matsuda. The population was divided into three clusters: CN with normal values, CIR with IR and Ca with values in between. The number of individuals classified in each CIr was very different according to each method. With the cut-off values obtained, for each method, the system for the evaluation of IR in elderly people was developed. Our work is intended to aid physicians in the early detection of IR by using information from diverse methods.
AB - The lack of standardized cut-off values for the surrogate methods to diagnose Insulin resistance (IR) and the fact that the sensitivity of these methods have been studied in specific populations have limited their use in clinical routine. We developed a system that could aide to diagnosis IR in elderly people, analyzing four surrogate methods of IR estimation using a k-means clustering algorithm. Study subjects included 119 nondiabetic participants over 65 year old from Ecuadorian highlands. Blood tests included a two-point oral glucose test tolerance. The k-means clustering algorithm, was applied in one-dimensional experiments for the Homa-IR, Quicki, Avignon and Matsuda. The population was divided into three clusters: CN with normal values, CIR with IR and Ca with values in between. The number of individuals classified in each CIr was very different according to each method. With the cut-off values obtained, for each method, the system for the evaluation of IR in elderly people was developed. Our work is intended to aid physicians in the early detection of IR by using information from diverse methods.
KW - Homa-IR
KW - K-means
KW - Quicki
KW - elderly
KW - insulin resistance
KW - unsupervided learning
UR - https://www.scopus.com/pages/publications/85045755959
U2 - 10.1109/ETCM.2017.8247554
DO - 10.1109/ETCM.2017.8247554
M3 - Contribución a la conferencia
AN - SCOPUS:85045755959
T3 - 2017 IEEE 2nd Ecuador Technical Chapters Meeting, ETCM 2017
SP - 1
EP - 6
BT - 2017 IEEE 2nd Ecuador Technical Chapters Meeting, ETCM 2017
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2nd IEEE Ecuador Technical Chapters Meeting, ETCM 2017
Y2 - 16 October 2017 through 20 October 2017
ER -