The purpose of this research is to evaluate the retention of synthetic water drugs using the cross -flow membranes cell SEPA CF II with nanofiltration (NF) membranes and inverse osmosis (RO), which currently have been little studied for the removal of this type of pollutants, especially antibiotics, which due to its characteristics accuses great involvement of the environment (induction Resistant). In the first part of the investigation, the conditioning and characterization of the membranes will be carried out, synthetic solutions will be prepared with the selected studies antibiotics based on the best -selling in the city of Cuenca (Ciprofloxacin and Sulfametozaxol) performing the quantification in the monkey and bicomponent solution at the entrance of the cell, permeated and rejected by chromatography HPLC, Where the best chromatographic conditions and subsequent validation of the method will be evaluated. The effectiveness of separation of the membranes will be announced and the influence of the operating conditions on the rejection of the pollutants (transmembrane pressure and tangential speed) will be studied, as well as the influence of the pH in their performance will be evaluated. The type of membranes dirty will be analyzed using optical microscopy and FT-IIR spectroscopy. A comparison of the effectiveness of the membranes studied of NF and RO will be made, as well as obtaining the best operating parameters.