Synthesis of nanofibers of biocompatible compound material based on biopolymers for bone tissue engineering applications

Poly alcohol (vinyl) is a multi-proposal polymer that contains an abundant hydroxyl group on its surface. In this document, composite scaffolding from materials based on polylactic nanofibers (pla) coated with a thin layer of poli alcohol (vinyl) (PVA) will be manufactured using hydrothermic treatments, in addition, the effects of deposition of the hydrophilic PVA in cell adhesion and differentiation of MC3T3-E1 osoblasts will be investigated by cell compatibility tests in cell Vitro. Both structural morphology, interface chemical bonds, and the thermal and mechanical properties of scaffolding will be studied. Different analyzes will verify that the thin layer of PVA will be successfully deposited on the surface of the plans manufactured by the electrohilation technique (ectrospinning). Hydrothermal processes will induce a crystalline conformation due to the improved Mobility of the PLA. The results of its mechanical properties will show that these properties of the PLA can be changed from rigid to ductiles with a substantial improvement in its tension resistance, this due to the maximization in the interaction of hydrogen bonds during thermal treatment and the presence of PVA. The adhesion and proliferation properties of MC3T3-E1 cells in scaffolding of compound material will be greater than in non-coated fibers. Based on experimental results, the manufacture of plas of PVA covered with PVA can be of particular interest in tissue engineering and bone tissue regeneration.

13th UNIVERSITY RESEARCH PROJECT COMPETITION