Factors associated with the therapeutic response in asthmatic children in the context of Sarscov-2

Background: viral infections, therapeutic adhesion and genetic factors have been associated with asthma control. Severe asthma could be a risk factor for Mortality by SARS-COV-2 infection. Objective: Analyze the factors associated with the therapeutic response in asthmatic children aged 5 to 17 years in the context of SARS-COV-2 and identify barriers and facilitators of asthma self-care. Methods: A Mixed Quantitative Observational, and qualitative phenomenological study in asthmatic children of 5-17 years in Cuenca-Ecuador will be carried out. Data will be collected through questionnaires applied to parents about asthma attacks, risk factors, knowledge, control and costs associated with asthma. Blood samples will be taken at the time of recruitment to analyze genotipification and expression in the NR3C1, ADRB2, ADCy9 and ACE genes. The quantification of IgM and IgG Anti-Sars-COV-2 antibodies will be performed by enzymatic immunoassay. A second blood sample will be taken at six months after the recruitment to estimate anti-Sars-COV-2 antibodies. The identification of barriers and facilitators associated with the automanejo of asthma will be carried out through a phenomenological qualitative analysis using in -depth interviews. Quantitative data will be analyzed in Stata, qualitative data will be analyzed using the NVIVO software. Logistic regression models will be used for the analysis of genetic variants and Poison regressions for prospective data. Expected results: The results of this study will allow the description of the factors associated with the therapeutic response in children with asthma in the context of SARS-COV 2. The results generated will identify the factors associated with the response to the treatment of child asthma and apply preventive measures.

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