Molecular detection and typification of bovine papilloma virus of animal injuries affected by papillomatosis and voaturia enzotic bovine.

Bovine papillomatosis is an infectotransmissible disease caused by one of the 13 types of bovine papilloma virus, the consequence of viral infection are characterized by dispersed neoplastic growth or groups, located in the keratinized body epithelium Pteridium causes Enzootic bovine bladder hematuria, in which injuries can evolve malignification due to exposure to mutagen compounds from these plants. Depending on the number, size and location of the lesions, they can have an important impact on the productivity of animals, and can even be the cause of their death. For the control and prevention of this disease, immunotherapy and immunoprophylaxis based on autoimmunization and immunization with experimental vaccines have been successfully used; However, the diversity at the antigenic level of the 13 types of viruses can have a negative impact on the effectiveness of immune tools, as happens in the case of human papillomavirus in which multivalent vaccines should be used. A possible solution to this problem is the generation of multivalent vaccines and immunotherapeutics with the most frequent bovine papillomavirus types in a certain region, unfortunately this information has not been generated in Ecuador. Therefore, the development, validation and implementation of a PCR test for the detection and one of RFLP is proposed for the identification of the types of causal bovine papilloma viruses of the lesions found in the animals affected by papillomatosis and vesical hematuria Enzootic bovine, to generate data that based the development of immunotherapy and prophylaxis strategies Recombinants has been used in the control and prevention of this disease.

XIII UNIVERSITY COMPETITION FOR RESEARCH PROJECTS